PARP Inhibition in Breast Cancer

In this animation, we were tasked with explaining the role of Poly(ADP-ribose) polymerase (PARP) inhibitors as a treatment for breast cancer patients with BRCA1 and BRCA2 mutations. We explain how PARP is a protein involved in repairing single-stand breaks in DNA, and inhibition of this enzyme prevents DNA repair, resulting in the accumulation of single-strand breaks. During DNA replication, these single-strand breaks lead to double-strand breaks, ultimately resulting in tumour cell apoptosis. PARP inhibitors are most promising in the treatment of breast and ovarian cancers, given relatively high rates of BRCA1/2 mutations in these malignancies.

Deliverables

Oncology event animation, educational material

Client

Undisclosed / Confidential

PARP Inhibition in Cancer 3D Animation
PARP Inhibitors in Breast Cancer 3D Animation

What are PARP Inhibitors

PARP helps repair DNA when it becomes damaged. DNA damage may be caused by many things, including exposure to UV light, radiation, certain anticancer drugs, or other substances in the environment.

In cancer treatment, blocking PARP may help keep cancer cells from repairing their damaged DNA, causing them to die. PARP inhibitors are a type of targeted therapy. Also called poly (ADP-ribose) polymerase inhibitor.

reference: NIH - National Cancer Institute

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