PARP Inhibition in Breast Cancer
In this animation, we were tasked with explaining the role of Poly(ADP-ribose) polymerase (PARP) inhibitors as a treatment for breast cancer patients with BRCA1 and BRCA2 mutations. We explain how PARP is a protein involved in repairing single-stand breaks in DNA, and inhibition of this enzyme prevents DNA repair, resulting in the accumulation of single-strand breaks. During DNA replication, these single-strand breaks lead to double-strand breaks, ultimately resulting in tumour cell apoptosis. PARP inhibitors are most promising in the treatment of breast and ovarian cancers, given relatively high rates of BRCA1/2 mutations in these malignancies.
Oncology event animation, educational material
Undisclosed / Confidential